Semax
A synthetic heptapeptide derived from ACTH(4-7) with a Pro-Gly-Pro C-terminal extension. Extensively researched in the Russian literature for neuroprotection, BDNF upregulation, and cognitive enhancement.
For laboratory and in vitro research purposes only. Not for human consumption.
What is Semax?
Semax is a synthetic heptapeptide derived from the ACTH(4-7) sequence, with a Pro-Gly-Pro extension added to increase its stability and CNS activity duration. Developed by Russian researchers, it has been approved as a pharmaceutical in Russia for clinical use in stroke recovery, optic nerve disease, and ADHD. Research has focused on its ability to increase BDNF levels, protect neurons from ischemic damage, and modulate dopaminergic and serotonergic systems in preclinical models.
bdnf. neuroprotection.
developed by russian researchers.
Semax originated as a pharmaceutical compound — approved in Russia for stroke recovery and neurological disorders. International researchers have focused on its ability to upregulate BDNF (brain-derived neurotrophic factor), protect neurons from ischemic damage, and modulate dopaminergic and serotonergic systems.
How Semax works in research models
Semax is a modified fragment of ACTH with the Pro-Gly-Pro tail added to extend stability. Research demonstrates that Semax upregulates BDNF (brain-derived neurotrophic factor), NGF, and VEGF expression in hippocampal and cortical tissue. It activates the serotonergic and dopaminergic systems and has shown neuroprotective effects in models of ischemia, stroke, and oxidative stress.
approved in russia.
studied for brain resilience.
Unlike many research peptides that exist only in preclinical science, Semax has a clinical approval track record. It has been used in hospitals for stroke recovery in Russia — one of the more substantial neuropeptide clinical datasets in the research literature.
Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents.
Neurosci Lett · 2005 · PMID: 15694258
Neuroprotective effect of Semax in rats with experimental ischemic stroke.
Mol Biol · 2010 · PMID: 21137187
Published research uses intranasal or subcutaneous administration at 0.1–0.5 mg/kg in rodent models. The intranasal route demonstrates rapid CNS penetration due to olfactory nerve transport. Reconstitute with sterile water for intranasal use. Store reconstituted solution at 4°C.
You ask, we answer.
Yes. Semax is registered as a pharmaceutical in Russia, where it is used clinically for stroke recovery, ADHD, peptic ulcers, and optic nerve disease. It is not approved by the FDA.
Semax is derived from the ACTH(4-7) sequence (Met-Glu-His-Phe) with a synthetic Pro-Gly-Pro tail. This modification extends its stability and duration of CNS activity compared to the parent ACTH fragment, while removing the cortisol-stimulating activity of full ACTH.
BDNF (brain-derived neurotrophic factor) is a protein that supports the survival of existing neurons and encourages the growth of new neurons and synapses. Research showing Semax upregulates BDNF in hippocampal and cortical tissue has made it of interest to researchers studying neuroprotection, cognitive function, and neuroplasticity.
Yes. Published research describes both intranasal and intraperitoneal administration in animal models. Intranasal delivery is noted for rapid CNS penetration via olfactory nerve transport — bypassing the blood-brain barrier. The Russian pharmaceutical form of Semax is supplied as a nasal spray.
Research Use Only
All Rowan Peptides products are intended strictly for laboratory and in vitro research purposes. They are not approved by the FDA and are not intended for human consumption, veterinary use, or any therapeutic application. By purchasing, you agree to our Terms of Service and Indemnity Waiver. Rowan Peptides LLC operates as a chemical supplier only.
Cognitive research using ACTH analogues. Semax is one I've tried from four different vendors at this point and Rowan's is noticeably cleaner going by the COA. 30mg is a good vial size for protocol flexibility. The BDNF research angle is well documented on their site.
Brain chemistry research. Semax is a compound where the Russian origin means sourcing is tricky. Rowan's is third party verified and that's what sold me. Happy with it.
Got both Semax and Selank on this order. Semax arrived in perfect condition, nice tight lyophilized cake. Reconstituted with no issues. The Cognitive Stack discount on my next order is already noted.
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