Selank
A synthetic heptapeptide combining the tuftsin sequence with Gly-Pro-Pro. Studied for its anxiolytic properties and nootropic effects with a mechanism distinct from benzodiazepines.
For laboratory and in vitro research purposes only. Not for human consumption.
What is Selank?
Selank is a synthetic heptapeptide that combines the tuftsin sequence with a stabilizing Gly-Pro-Pro extension. Tuftsin is an endogenous peptide with both immune-modulating and neuromodulating properties. Selank has been studied primarily for anxiolytic effects that work differently than benzodiazepines — modulating the GABAergic system indirectly rather than binding benzodiazepine receptors directly. It doesn't appear to produce sedation, tolerance, or dependence in preclinical models. It is approved as a pharmaceutical in Russia.
anxiolytic effects.
without the benzodiazepine profile.
Benzodiazepines directly bind GABA receptors — producing anxiolysis but also sedation and dependence risk. Selank modulates the GABAergic system indirectly, without direct receptor binding. Preclinical research shows it reduces anxiety-related behaviour without the sedation or tolerance associated with classical anxiolytics.
How Selank works in research models
Selank is a stable analogue of the endogenous peptide tuftsin. Research indicates Selank modulates the GABAergic system (without direct benzodiazepine receptor binding), increases BDNF levels, and stabilises enkephalin metabolism — reducing anxiety-related behaviour in animal models without the sedation, tolerance, or dependence associated with classical anxiolytics.
gaba. bdnf. enkephalins.
three different pathways.
Selank's mechanism involves three distinct pathways: indirect GABAergic modulation, upregulation of BDNF, and stabilization of enkephalin metabolism. Researchers studying anxiolysis without dependence risk find this multi-pathway profile of particular interest.
Heptapeptide Selank and its analogues modulate the central serotonergic system.
Dokl Biol Sci · 2009 · PMID: 19435019
Pharmacokinetics of selank administered intranasally and intraperitoneally.
Bull Exp Biol Med · 2010 · PMID: 21116465
Research models in rodents use 25–300 mcg/kg via intranasal or intraperitoneal routes. Intranasal delivery is common in human clinical research due to rapid CNS uptake. Reconstitute with sterile water for intranasal application. Store at 4°C after reconstitution.
You ask, we answer.
Benzodiazepines act directly on GABAA receptors, producing anxiolysis but also sedation, muscle relaxation, and dependence risk. Selank modulates GABA indirectly, without direct receptor binding, and does not appear to produce sedation or tolerance in preclinical models.
Tuftsin is an endogenous tetrapeptide (Thr-Lys-Pro-Arg) with immunostimulatory and neuromodulatory properties. Selank extends tuftsin with a Pro-Gly-Pro sequence to improve stability and CNS penetration.
Selank is registered as a pharmaceutical in Russia, where it is used clinically for generalized anxiety disorder, phobias, and as a nootropic. It has not been approved by the FDA or EMA.
Preclinical research in rodent models has not demonstrated tolerance or dependence with Selank administration, in contrast to classical GABAA-positive allosteric modulators like benzodiazepines. This is attributed to its indirect rather than direct GABA receptor mechanism.
Research Use Only
All Rowan Peptides products are intended strictly for laboratory and in vitro research purposes. They are not approved by the FDA and are not intended for human consumption, veterinary use, or any therapeutic application. By purchasing, you agree to our Terms of Service and Indemnity Waiver. Rowan Peptides LLC operates as a chemical supplier only.
Part of my neurotransmitter research stack. Good clean compound from Rowan. Same quality I've come to expect across everything they sell.
First order was selank. Ordered it based on the page description which was clear without being hype. Vial arrived well. Definitely coming back for the cognitive stack bundle.
Anxiolytic research using GABAergic peptides. Selank is underresearched in Western literature but the mechanism is solid. Rowan's 5mg vial is cleanly sourced, COA verified, and the enkephalin analogue data on their site actually reflects the literature accurately.
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