AOD-9604
A modified fragment (residues 176–191) of human growth hormone. Studied for its selective lipolytic activity without the insulin-sensitising effects associated with full-length hGH.
For laboratory and in vitro research purposes only. Not for human consumption.
What is AOD-9604?
AOD-9604 is a modified fragment of human growth hormone — specifically residues 176 to 191 of the C-terminal region. It was isolated by researchers studying which part of the GH molecule is responsible for fat metabolism. Unlike full-length growth hormone, AOD-9604 appears to stimulate fat breakdown (lipolysis) without activating the IGF-1 axis or significantly affecting blood glucose. This selective fat-metabolizing profile makes it a useful research tool for studying body composition mechanisms in isolation.
the fat-metabolizing fragment
of growth hormone.
AOD-9604 is the C-terminal fragment of human growth hormone identified as responsible for its lipolytic activity. Research shows it stimulates fat breakdown via β3-adrenergic receptors without the insulin-affecting, IGF-1-elevating effects of full GH — giving researchers a cleaner tool for studying fat metabolism specifically.
How AOD-9604 works in research models
AOD-9604 corresponds to the C-terminal domain of human growth hormone believed to regulate fat metabolism. Research indicates it stimulates lipolysis (fat breakdown) and inhibits lipogenesis through activation of β3-adrenergic receptors. Unlike intact hGH, AOD-9604 does not appear to activate the IGF-1 axis or significantly affect blood glucose.
selective lipolysis.
without the igf-1 effects.
The key distinction in AOD-9604 research: it appears to activate the fat-burning pathways of GH without triggering the anabolic and insulin-modulating effects. AOD-9604 even reached Phase IIb clinical trials before development was halted for commercial reasons.
The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knockout mice.
Endocrinology · 2001 · PMID: 11356005
Metabolic studies of a growth hormone-releasing peptide (AOD9604) in obese mouse and pig models.
J Pediatr Endocrinol Metab · 2000 · PMID: 10905386
Preclinical studies have used doses of 250–500 mcg/kg in rodent models. Reconstitute with bacteriostatic water. Store reconstituted solution at 4°C and use within 30 days.
You ask, we answer.
Yes. AOD-9604 is a synthetic peptide corresponding to residues 176–191 of the C-terminal region of human growth hormone. It was specifically isolated for studying the fat-metabolising properties of hGH.
Published research suggests AOD-9604 does not significantly affect fasting blood glucose, insulin sensitivity, or IGF-1 levels at typical research doses — in contrast to intact hGH.
AOD stands for Anti-Obesity Drug. The compound was originally developed by Metabolic Pharmaceuticals in Australia as a potential obesity treatment, and reached Phase IIb clinical trials before development was halted for commercial rather than safety reasons.
Yes. AOD-9604 underwent Phase I, II, and IIb clinical trials. The trials demonstrated acceptable safety profiles and showed statistically significant fat loss in obese subjects over 12 weeks. Phase III trials were not pursued due to commercial decisions by the developer.
Research Use Only
All Rowan Peptides products are intended strictly for laboratory and in vitro research purposes. They are not approved by the FDA and are not intended for human consumption, veterinary use, or any therapeutic application. By purchasing, you agree to our Terms of Service and Indemnity Waiver. Rowan Peptides LLC operates as a chemical supplier only.
Good product, solid sourcing. The compound information on the site is accurate without being sensationalized which is how I like it. Fourth Rowan product I've tried, all consistent.
The fat metabolism research around AOD-9604 is interesting and Rowan's breakdown on the page is actually one of the better summaries I've read. The compound itself arrived exactly as described. Good experience.
Added this to a research protocol alongside tesamorelin. Came in fast, COA inside, vial sealed properly. The 2mg dosing is right for what I needed. Rowan has become the only brand I use at this point.
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