Epithalon
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) first developed at the St. Petersburg Institute of Bioregulation. Studied for telomerase activation and pineal gland modulation.
300 in stock
For laboratory and in vitro research purposes only. Not for human consumption.
What is Epithalon?
Epithalon is a synthetic tetrapeptide — just four amino acids — originally derived from bovine pineal gland extract by researchers at the St. Petersburg Institute of Bioregulation. It has been studied primarily for two properties: the ability to activate telomerase in somatic human cells (leading to telomere elongation in laboratory studies), and modulation of the hypothalamic-pituitary-pineal axis, normalizing melatonin and cortisol rhythms in aged research subjects. It has one of the longest longevity research records of any peptide compound — dating back to the 1970s.
telomeres. melatonin.
forty years of research.
Epithalon's research history dates back to the 1970s at the St. Petersburg Institute of Bioregulation. Researchers documented telomerase activation in human somatic cells, telomere elongation, and normalized melatonin rhythms in aged subjects. Forty years of data on a four-amino-acid molecule.
How Epithalon works in research models
Epithalon (Epitalon) is a tetrapeptide bioregulator first synthesised from an extract of the bovine pineal gland. Research has identified two principal mechanisms: telomerase activation in somatic human cells (leading to telomere elongation), and modulation of the hypothalamic-pituitary-pineal axis, normalising melatonin and cortisol rhythms in aged research subjects. Longevity studies in rodent models have demonstrated increased median and maximum lifespan.
the pineal peptide.
studied since the 1970s.
Few peptides have a research record as long as Epithalon's. From early longevity studies to modern in vitro telomerase research, it remains one of the most studied bioregulatory peptides in the longevity space. Rowan Epithalon ships at ≥99.1% HPLC purity with a lot-specific COA.
Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.
Biogerontology · 2003 · PMID: 14501183
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.
Bull Exp Biol Med · 2003 · PMID: 14514061
Epitalon activates the chromatin at the old animals.
Neuro Endocrinol Lett · 2012 · PMID: 23183529
Research protocols in published literature describe 5–10 mg total doses administered in cyclical patterns (typically 10-day cycles repeated 2–4 times per year) in rodent and primate studies. Reconstitute with sterile or bacteriostatic water. Store reconstituted solution at 4°C and use within 30 days.
You ask, we answer.
Yes. Epithalon and Epitalon are two transliterations of the same compound from Russian literature. They refer to the identical tetrapeptide Ala-Glu-Asp-Gly.
The published cyclical dosing protocols use cumulative doses that make 10mg a practical research quantity for a single treatment cycle in rodent models.
The telomerase activation studies have been conducted in human somatic cell cultures (in vitro). In vivo longevity research to date is primarily in rodent models. No randomised controlled clinical trials have been conducted.
Telomerase is an enzyme that repairs and extends telomeres — the protective end-caps on chromosomes that shorten with each cell division. Shortened telomeres are associated with cellular senescence and aging. Research showing Epithalon can activate telomerase in somatic human cells (which normally don't express it) is what positioned it as a longevity research compound.
Published protocols typically describe cyclical dosing — commonly 10-day courses repeated 2–4 times per year in rodent and primate research. This cyclical approach is derived from the original bioregulator research framework developed at the St. Petersburg Institute.
Research Use Only
All Rowan Peptides products are intended strictly for laboratory and in vitro research purposes. They are not approved by the FDA and are not intended for human consumption, veterinary use, or any therapeutic application. By purchasing, you agree to our Terms of Service and Indemnity Waiver. Rowan Peptides LLC operates as a chemical supplier only.
Second order. First one convinced me this is my longevity peptide source going forward. The site links out to actual research rather than hiding behind vague claims. Tells you a lot.
Been researching telomere biology for a while. Epithalon is one I've had a hard time sourcing cleanly. Rowan's 10mg vial arrived well sealed, the lyophilization looked right, reconstituted properly. The COA is on their site with the lot number from my order. That's the standard.
Ordered the Longevity Stack but writing this review for epithalon specifically because it's the compound I was most skeptical about. Quality was there.
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