Ipamorelin
A selective, pentapeptide growth hormone secretagogue. Studied for its highly specific GH-releasing profile without concurrent stimulation of cortisol or prolactin.
500 in stock
For laboratory and in vitro research purposes only. Not for human consumption.
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide — just five amino acids — that selectively activates the ghrelin receptor (GHS-R1a) on pituitary cells to stimulate growth hormone release. What distinguishes it in research is its selectivity: unlike earlier growth hormone secretagogues, Ipamorelin produces GH release without significantly increasing cortisol, prolactin, or ACTH at research doses. It is studied for its clean hormonal profile and its role in understanding pulsatile GH secretion.
selective gh release.
without the cortisol spike.
Earlier growth hormone secretagogues triggered GH release but also elevated cortisol and prolactin. Ipamorelin changed the research picture — at doses producing maximal GH release, it does not significantly stimulate cortisol or prolactin, giving researchers a cleaner tool for studying the GH axis in isolation.
How Ipamorelin works in research models
Ipamorelin acts as a selective agonist at the ghrelin receptor (GHS-R1a) on pituitary somatotrophs, stimulating pulsatile growth hormone release. Its selectivity profile is a defining research characteristic: at doses producing maximal GH release, it does not significantly stimulate cortisol, prolactin, or ACTH secretion — unlike earlier generation GHS compounds such as GHRP-2 or GHRP-6.
five amino acids.
one of the cleanest gh
tools in research.
Ipamorelin's selectivity for GHS-R1a is what makes it a preferred research compound for GH studies. Rowan Ipamorelin is verified at ≥99.3% HPLC purity, mass spec confirmed, with a lot-specific COA from Janoshik Analytical.
Ipamorelin, the first selective growth hormone secretagogue.
Eur J Endocrinol · 1998 · PMID: 9849822
Evidence for acyl ghrelin modulation of growth hormone release in the fed state.
J Clin Endocrinol Metab · 2008 · PMID: 18957498
Published preclinical research uses doses of 1–3 mg/kg in rodent models. Ipamorelin has a short half-life (~2 hours), which informs the pulsatile dosing protocols described in the literature. Reconstitute with bacteriostatic water and store at 4°C after reconstitution.
You ask, we answer.
GHRP-6 stimulates GH release but also significantly increases cortisol, prolactin, and ACTH. Ipamorelin's selectivity for GHS-R1a produces a cleaner GH-release profile, making it a preferred research tool for isolating GH-related mechanisms.
Supplied as Ipamorelin acetate, consistent with published research standards.
A growth hormone secretagogue (GHS) is a compound that stimulates the pituitary gland to release growth hormone. Unlike exogenous GH administration, secretagogues work through the body's own regulatory pathways — triggering the pituitary to produce and release GH rather than replacing it externally.
Ipamorelin has a short half-life of approximately 2 hours in animal models. This short duration informs dosing protocols in published research, which typically use multiple daily administrations to maintain GH pulsatility.
Yes — Ipamorelin and CJC-1295 (no DAC) are one of the most commonly paired combinations in GH research. CJC-1295 stimulates GHRH receptors while Ipamorelin activates the ghrelin receptor (GHS-R1a). They work through different pituitary pathways, and research suggests their combination produces a synergistic GH release greater than either compound alone.
Research Use Only
All Rowan Peptides products are intended strictly for laboratory and in vitro research purposes. They are not approved by the FDA and are not intended for human consumption, veterinary use, or any therapeutic application. By purchasing, you agree to our Terms of Service and Indemnity Waiver. Rowan Peptides LLC operates as a chemical supplier only.
Fifth order from Rowan across different peptides. Ipamorelin is one I come back to consistently. Never had a bad vial. The purity consistency is what you want in a research supplier.
Rowan was recommended in a longevity forum I'm in. Started with ipamorelin as a lower-stakes test order. Vial arrived sealed, reconstituted perfectly. The branding is clearly thought through which sounds like a weird thing to say about a research vendor but it actually matters to me as a signal of how much they care about what's inside the vial.
Solid. Reconstituted well, no issues. Shipping took 4 days which is slightly longer than usual but not a problem. Everything else was on point.
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