CJC-1295 (No DAC)
A synthetic analogue of Growth Hormone Releasing Hormone (GHRH). The no-DAC form produces physiological pulsatile GH release rather than sustained elevation.
500 in stock
For laboratory and in vitro research purposes only. Not for human consumption.
What is CJC-1295 (No DAC)?
CJC-1295 (no DAC) is a synthetic analogue of growth hormone-releasing hormone (GHRH) — the signal your hypothalamus uses to tell the pituitary gland to release growth hormone. The "no DAC" version lacks the drug affinity complex modification, giving it a half-life of approximately 30 minutes that closely mirrors natural GHRH pulsatility. Researchers use it to study the hypothalamic-pituitary-GH axis, sleep-associated GH release, and body composition mechanisms.
natural ghrh pattern.
pulsatile. physiological.
CJC-1295 without DAC has a ~30-minute half-life that mimics the natural GHRH pulse from the hypothalamus. Researchers use it to study pulsatile GH secretion — particularly the large GH pulse that occurs during slow-wave sleep. It's the most physiologically accurate GHRH analogue available.
How CJC-1295 (no DAC) works in research models
CJC-1295 without DAC binds to and activates GHRH receptors on anterior pituitary somatotrophs, stimulating GH and downstream IGF-1 release. Without the DAC modification, it retains a half-life of approximately 30 minutes — closely mimicking the natural GHRH pulse — in contrast to the DAC version, which produces continuous GH elevation over days.
no dac means
natural pulse pattern.
The DAC modification in some CJC-1295 variants extends half-life to days, producing continuous GH elevation. Without DAC, the short half-life mimics natural GHRH rhythm — a critical distinction for researchers studying physiological GH dynamics.
Prolonged stimulation of GH and IGF-1 secretion by CJC-1295, a long-acting GHRH analogue.
J Clin Endocrinol Metab · 2006 · PMID: 16352683
Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295.
J Clin Endocrinol Metab · 2006 · PMID: 16396996
CJC-1295 (no DAC) is typically studied at 1–2 mcg/kg in clinical-adjacent research models, often administered before sleep to coincide with endogenous GH pulsatility. Reconstitute with bacteriostatic water and store at 4°C.
You ask, we answer.
The DAC (Drug Affinity Complex) modification allows CJC-1295 to bind to albumin, extending its half-life to 6–8 days and causing sustained, non-pulsatile GH elevation. The no-DAC form has a ~30-minute half-life, producing pulsatile GH release that more closely mimics natural physiology.
The bulk of endogenous GH is secreted during slow-wave sleep. Research into GHRH analogues like CJC-1295 frequently examines this sleep-associated secretory axis, making sleep physiology a central research context.
Yes — this is one of the most commonly paired combinations in GH research. CJC-1295 stimulates GHRH receptors on pituitary somatotrophs, while Ipamorelin activates the ghrelin receptor (GHS-R1a). They work through different pituitary pathways and research suggests their combination produces a synergistic GH release greater than either compound alone.
DAC stands for Drug Affinity Complex — a chemical modification that allows CJC-1295 to bind to albumin in the bloodstream, extending its half-life from ~30 minutes to 6–8 days. CJC-1295 with DAC produces sustained, non-pulsatile GH elevation. Without DAC, the peptide acts more like natural GHRH — shorter, pulsatile, and more physiological.
Research Use Only
All Rowan Peptides products are intended strictly for laboratory and in vitro research purposes. They are not approved by the FDA and are not intended for human consumption, veterinary use, or any therapeutic application. By purchasing, you agree to our Terms of Service and Indemnity Waiver. Rowan Peptides LLC operates as a chemical supplier only.
Running a GH research protocol. Switched to Rowan from a vendor I'd been using for 18 months because I kept reading about their Janoshik testing. The difference in how they present the compound data is noticeable. 2mg vial, exactly what was described.
Clean, fast, properly sealed. The insert with the lot number is a detail I didn't expect but now I expect from everyone. Spoiled.
Always order the Growth Stack but this time ordered individually to compare. Same quality. That's all I needed to know.
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