TB-500
A synthetic 44-amino acid fragment of Thymosin Beta-4, studied for its role in actin regulation, cell migration, and tissue repair in preclinical models.
499 in stock
For laboratory and in vitro research purposes only. Not for human consumption.
What is TB-500?
TB-500 is a synthetic 44-amino acid peptide fragment corresponding to the actin-binding domain of Thymosin Beta-4, a protein found naturally in virtually every cell in the body. It is studied for its role in regulating actin — a structural protein critical to cell movement and tissue repair. In preclinical research, TB-500 has been examined in cardiac, skeletal muscle, tendon, and vascular injury models. It is commonly studied alongside BPC-157 as a complementary healing research tool.
recover faster.
the research backs it.
TB-500 targets the actin-binding domain of Thymosin Beta-4 — the region believed to drive most of the protein's tissue-repair activity. It has been studied in cardiac muscle, skeletal muscle, tendons, and vascular tissue. A versatile compound for recovery-focused preclinical research.
How TB-500 works in research models
TB-500 corresponds to the actin-binding domain of Thymosin Beta-4. It promotes actin monomer (G-actin) sequestration, regulating the balance between filamentous and globular actin within cells. This regulation enables enhanced cell migration and differentiation — mechanisms central to wound healing and tissue remodeling. Research in cardiac and skeletal muscle models has demonstrated significant regenerative properties in preclinical settings.
44 amino acids.
studied across cardiac, muscle,
and tendon models.
Published research has examined TB-500 across multiple tissue types. The actin polymerization mechanism it targets is fundamental to how cells move and repair — making it one of the most broadly studied healing peptides in preclinical science.
Thymosin β4: a multifunctional regenerative peptide. Basic properties and clinical applications.
Expert Opin Biol Ther · 2012 · PMID: 22500545
Cardiac and skeletal muscle effects in the mouse model of Duchenne muscular dystrophy.
J Mol Med · 2014 · PMID: 24337399
Thymosin β4 induces adult epicardial progenitor mobilization and neovascularization.
Nature · 2007 · PMID: 17568746
Preclinical studies typically administer TB-500 at 2–2.5 mg/kg in rodent models. Reconstitute with bacteriostatic water. Store reconstituted solution at 4°C and use within 30 days.
You ask, we answer.
Thymosin Beta-4 is the full 43-amino acid endogenous protein. TB-500 is a synthetic fragment corresponding specifically to the actin-binding domain, which is believed to be responsible for the majority of the bioactivity.
Lyophilised TB-500 stored at −20°C in a desiccated environment is stable for 24+ months. Avoid freeze-thaw cycles once reconstituted.
Yes, and this is one of the most common combinations in preclinical healing research. BPC-157 and TB-500 work through distinct mechanisms — BPC-157 via angiogenesis and FAK-paxillin signaling, TB-500 via actin polymerization — making them complementary. Many researchers use both together in injury recovery models.
Published preclinical research has examined TB-500 in cardiac muscle, skeletal muscle, tendon, ligament, vascular endothelium, and corneal tissue models. The actin-regulation mechanism it targets is relevant across virtually all tissue types that undergo repair.
Reconstituted TB-500 stored at 4°C is typically used within 30 days. The lyophilized form, stored at −20°C in a desiccated environment, is stable for 24+ months.
Research Use Only
All Rowan Peptides products are intended strictly for laboratory and in vitro research purposes. They are not approved by the FDA and are not intended for human consumption, veterinary use, or any therapeutic application. By purchasing, you agree to our Terms of Service and Indemnity Waiver. Rowan Peptides LLC operates as a chemical supplier only.
Grad student doing tissue repair research. Quality control here is tighter than some academic supply vendors I've used. That's not an exaggeration.
Friend kept talking about Rowan, finally tried it. 5mg vial, reconstituted perfectly. Shipping was fast. The packaging is honestly the nicest I've seen for a research peptide brand, it feels like something from an actual lab supply company.
New to peptide research. Came here after reading the PubMed links on the product page. Appreciated that nothing on the site makes claims it can't back up. The BAC water add-on reminded me of something I would have totally forgotten. Good experience start to finish.
Third order. Always TB-500. Consistent every single time and that is genuinely harder to find than you'd think in this market. Will keep coming back.
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